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Dysbiosis promotes a shift in TRP metabolism away from 5-HT and toward KYN, QA, and 3-HK, while simultaneously impairing intestinal barrier integrity and driving low-grade systemic inflammation, exaggerated cortisol reactivity, HPA-axis dysregulation, visceral adiposity, and cardiometabolic risk all features commonly comorbid with depression [178,179,180,181,182]
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10.5958/j.2231-1750.3.1.005 17 AshrafM.FooladM
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